Selected Publications

Chun Yi Ng, Khang Leng Lee, Mark D Muthiah, Kan Xing Wu, Florence W Chioh, Konstanze Tan, Gwyneth ST Soon, A Shabbir, WM Loo, ZS Low, QF Chen, Tan Nguan Soon, Ng Huck Hui, Dan Yock Young, Christine Cheung.
Crosstalk between endothelial and effector immune cells contributes to vascular injury in non-alcoholic ​ fatty liver disease. 
EMBO Reports (2022) e54271.

LT Ang, A Nguyen, KJ Liu, A Chen, X Xiong, M Curtis, RM Martin, BC Raftry, Chun-Yi Ng, U Vogel, A Lander, BJ Lesch, JL Fowler, AR Holman, T Chai, Y Yang, S Vijayakumar, FP Suchy, T Nishimura, J Bhadury, MH Porteus, H Nakauchi,Christine Cheung, SC George, K Red-Horse, JB Prescott & KM Loh.
Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses.
Cell (2022). DOI: 10.1016/j.cell.2022.05.024

Kan Xing Wu, Natalie JY Yeo, Chun-Yi Ng, Florence W Chioh, Qiao Fan, Xianfeng Tian, Teresa B Yang, Gunaseelan Narayaan, Hui Min Tay, Han Wei Hou, N Ray Dunn, Xinyi Su, Gemmy CM Cheung, Christine Cheung.
Hyaluronidase-1 impairs endothelial barrier integrity in polypoidal choroidal vasculopathy.
BMC Biology. 2022; 20:47, doi: 10.1186/s12915-022-01244-z

Kai Yi Tay, Kan Xing Wu, Florence WJ Chioh, Matias I Autio, Nicole MQ Pek, Narmada BC, Sock-Hwee Tan, Adrian F Low, Michelle M Lian, Elaine GY Chew, Hwee Hui Lau, Adrian KK Teo, Jia Nee Foo, Roger SY Foo, Chew Kiat Heng, Mark YY Chan, Christine Cheung.
Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease.
Atherosclerosis (2022). DOI: 10.1016/j.atherosclerosis.2022.10.012

Bingwen Eugene Fan, Shiun Woei Wong, Christina Lai Lin Sum, Gek Hsiang Lim, Bernard PuiLam Leung, Chuen Wen Tan, Kollengode Ramanathan, Rinkoo Dalan, Christine Cheung, Xin Rong Lim, Mucheli Shravan Sadasiv, David Chien Lye, Barnaby Edward Young, Eng Soo Yap, Yew Woon Chia, The COVID-19 Clotting and Bleeding Investigators.
Persistent Hypercoagulability, Endotheliopathy and Inflammation in COVID-19 patients approximating 1 year after recovery.
American Journal of Hematology (2022). DOI: 10.1002/ajh.26575

​Florence WJ Chioh, Siew-Wai Fong, Barnaby E Young, Kan-Xing Wu, Anthony Siau, Shuba Krishnan, Yi-Hao Chan, Louis LY Teo, Fei Gao, Ru San Tan, Liang Zhong, Angela S Koh, Seow-Yen Tan, Paul A Tambyah, Laurent Renia, Lisa FP Ng, ​David C Lye, Christine Cheung.
Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation.
eLife 2021;10:e64909 DOI: 10.7554/eLife.64909

Vanessa Wazny, Anthony Siau, Kan Xing Wu, Christine Cheung.
Vascular underpinning of COVID-19
Open Biology. 2020 Aug;10(8):200208. doi: 10.1098/rsob.200208. Epub 2020 Aug 27.


Wilson Lek Wen Tan, Chukwuemeka George Anene-Nzelu, Eleanor Wong, Mick Lee, Hui San Tan, Sze Jing Tang, Arnaud Michel Yvon Perrin, Kan Xing Wu, Wen Hao Zheng, Robert John Ashburn, Bangfen Pan, May Yin Lee, Matias I Autio, Michael Morley, Wai Leong Tam, Christine Cheung, Kenneth B Margulies, Leilei Chen, Thomas P Cappola, Marie Loh, John Chambers, Shyam Prabhakar, Roger SY Foo.
Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype.
Circulation Research. 2020 Jun 12. doi: 10.1161/CIRCRESAHA.120.317254. Online ahead of print.


S Arora, S Lin, C Cheung, EKF Lim, Y Toh.
​Topography elicits distinct phenotypes and functions in human primary and stem cell derived endothelial cells.
​Biomaterials, 2020 Jan; doi: 10.1016/j.biomaterials.2019.119747 

​
Natalie Yeo, Ebenezer Chan, Christine Cheung.
Choroidal Neovascularization: Mechanisms of Endothelial Dysfunctions
​Frontiers in Pharmacology, 2019 Nov; 10: 1363. doi: 10.3389/fphar.2019.01363

​Titmarsh D, Nurcombe V, Cheung C, Cool SM.
Vascular Cells and Tissue Constructs Derived from Human Pluripotent Stem Cells for Toxicological Screening.
Stem Cells Dev. 2019 Aug 9. doi: 10.1089/scd.2018.0246.

Kiskin FN, Chang C,… Cheung C, et al.
Contribution of BMPR2 mutations and extrinsic factors in cellular phenotypes of pulmonary arterial hypertension.
American Journal of Respiratory and Critical Care Medicine, 2018 Jul 15;198(2):271-275. 


B.C. Narmada, Y.T. Goh, H. Li, S. Sinha, H. Yu, C. Cheung.
Human stem cell-derived endothelial-hepatic platform for efficacy testing of vascular-protective metabolites ​from nutraceuticals.
Stem Cells Translational Medicine, 2016 Mar;6(3):851-863.

​
J. Bargehr, L. Low, C. Cheung, W.G. Bernard, D. Iyer et al.
Embryological origin of human smooth muscle cells influences their ability to support vasculogenesis.
Stem Cells Reports, 2016 Jul; 5(7):946-59.

​C. Cheung, Y.T. Goh, J. Zhang, C. Wu, E. Guccione.
Modelling cerebrovascular pathophysiology in amyloid-β metabolism using neural crest-derived smooth muscle cells.
Cell Reports, 2014, 9(1):391-401.

​C. Cheung, A.S. Bernardo, R.A. Pedersen & S. Sinha.
Directed differentiation of embryonic origin-specific vascular smooth muscle subtypes from human pluripotent stem cells.
Nature Protocols, 2014, 9: 929–938.

L. Trigueros-M, J.M. Gonzalez-G, C. Cheung, P. Fernandez, F. Sanchez-Cabo et al.
Embryological-origin-dependent differences in homeobox expression in adult aorta: role in regional phenotypic variability and regulation of NF-κB activity.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33:1248-56.

​C. Cheung, A.S. Bernardo, M.W. Trotter, R.A. Pedersen & S. Sinha.
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Nature Biotechnology, 2012, 30 (2): 165-173.

C. Cheung & S. Sinha.
Human embryonic stem cell-derived vascular smooth muscle cells in therapeutic neovascularisation.
Journal of Molecular and Cellular Cardiology, 2011, 51 (5): 651-664.​